Leucemia prolinfocítica T variante de células cerebriformes: Presentación de un caso y revisión de la literatura

• Camila Peña ^[1] ; Ximena Valladares ^[1] ; Carolina Soto ^[1] ; Andrea Encina ^[1] ; Neda Marinov ^[1] ; María Soledad Undurraga ^[1] ; María Elena Cabrera ^[1]
  1. [1] Hospital del Salvador

     Hospital del Salvador

     Santiago, Chile

     
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 144, Nº. 1, 2016, págs. 124-128
• Idioma: español
• Títulos paralelos:
  • Cerebriform variant type of T cell prolymphocytic leukemia: Report of one case
• Enlaces
  • Texto completo
• Resumen

  • T cell Prolymphocytic Leukemia (T-PLL) is a rare and aggressive mature T cell Lymphocyte Leukemia. Twenty five percent of cases present as a small cell variant, and only 5% as a cerebriform variant. We report a 58 year-old man with rapidly progressive severe leukocytosis, skin lesions, lymphadenopathy, hepatosplenomegaly and pleural effusion. The lymphocytes had a cerebriform type. The diagnosis of T-PLL variant was made by morphology and immunophenotype study of peripheral blood. Karyotype was found to be complex. He was refractory to chemotherapy and died two months later.