Plomo y nefropatía: Biomarcadores urinarios en la detección de daño renal precoz

• Walter E Cabrera ^[1] ; Geert Behets ^[2] ; Ludwig Lamberts ^[2] ; Patrick D'Haese ^[2]
  1. [1] Universidad Católica Nuestra Señora de la Asunción

     Universidad Católica Nuestra Señora de la Asunción

     Paraguay

     
  2. [2] University of Antwerp

     University of Antwerp

     Arrondissement Antwerpen, Bélgica

     
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 144, Nº. 6, 2016, págs. 704-709
• Idioma: español
• Títulos paralelos:
  • Blood lead levels and markers of renal dysfunction among mechanical workshop workers
• Enlaces
  • Texto completo
• Resumen

  • The role of lead (Pb) as an environmental cause of nephropathy is difficult to ascertain due to the difficulty to determine clinically its exposure. Aim: To assess lead levels and renal function in a group of males working in mechanical workshops. Material and Methods: Blood and urine samples were obtained from 100 mechanical workshop workers aged 38 ± 16 years and 95 non-exposed office clerks aged 37 ± 17 years. Blood lead and creatinine levels were determined. In exposed workers, urinary excretion of intestinal alkaline phosphatases (IAP) and N-acetyl-glucosaminidase (NAG) were measured as early markers of renal failure. Results: Blood lead levels were 66.4 ± 43 and 33.6 ± 18 µg/L among mechanical workshop workers and non-exposed controls, respectively, p < 0.01. The figures for serum creatinine were 0.9 ± 0.1 and 0.9 ± 0.1 respectively, p = NS. Among exposed workers urinary excretion of IAP was 0.47 ± 0.6 U/L and of NAG, 0.92 ± 1.1 U/L. There was a positive correlation between blood lead levels and NAG excretion (r = 0.284) and IAP excretion (r = 0.346). Conclusions: Exposed workers had higher blood lead levels and there was a weak positive association between these levels and the urinary excretion of NAG and IAP.