Asociación entre obesidad y cáncer de ovario

• Macarena Valladares ^[1] ; Gino Corsini ^[1] ; Carmen Romero ^[2]
  1. [1] Universidad Diego Portales

     Universidad Diego Portales

     Santiago, Chile

     
  2. [2] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 142, Nº. 5, 2014, págs. 593-598
• Idioma: español
• Títulos paralelos:
  • Association between obesity and ovarian cancer
• Enlaces
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• Resumen

  • Obesity is a risk factor for cancer. Epidemiological evidences associate ovarian cancer with obesity. Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer and accounts for a high rate of mortality. The association between ovarian cancer and obesity could be explained by molecular factors secreted by adipose tissue such as leptin. In EOC, leptin increases cell proliferation and inhibits apoptosis. Additionally, adipose tissue synthesizes endogenous estrogens, which increase cell proliferation of epithelial ovarian cells. Also, obesity associated hyperinsulinism could increase ovarian estrogen secretion.