Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile

María Elena Cabrera; Guillermo Silva; Andrés Soto; Rodrigo Roselló; Constanza Castro; Virginia Martínez; Juan Ballesteros; Rodrigo Blamey; Claudia Garreaud

Ayuda

Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile

María Elena Cabrera ^[1] ; Guillermo Silva ^[2] ; Andrés Soto ^[2] ; Rodrigo Roselló ^[2] ; Constanza Castro ^[2] ; Virginia Martínez ^[1] ; Juan Ballesteros ^[2] ; Rodrigo Blamey ^[2] ; Claudia Garreaud ^[2]
1. [1] Universidad de Chile
  
  Universidad de Chile
  
  Santiago, Chile
2. [2] Hospital del Salvador
  
  Hospital del Salvador
  
  Santiago, Chile
Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 140, Nº. 2, 2012, págs. 243-250
Idioma: español
Títulos paralelos:
- HIV-related lymphoma in a public hospital in Chile. Analysis of 55 cases
Enlaces
- Texto completo
Resumen
- Background: Cancer is the third cause of death in patients infected with human immunodeficiency virus (HIV) and lymphoma is the most common type. Aim: To describe the clinical characteristics, histology, risk factors and prognosis of these patients, in a Chilean public hospital in Chile. Material and Methods: Records of 55 patients (45 males) aged between 23 and 67years with lymphoma and HIV positive serology, diagnosed between 1992-2008, were reviewed. Results: Six patients (11%) had Hodgkin lymphoma (HL) and the rest, non-Hodgkin lymphoma (NHL). B-cell phenotype constituted 83.7% of NHL cases. The most common subtypes of all the lymphoma were diffuse large B cell lymphoma in 24 cases (43.6%), Burkitt lym-phoma in 12 cases (21.8%), andplasmablastic lymphoma in 5 cases (9.1%). Thirty five patients (64%) underwent curative intended chemotherapy (CT) concomitantly with highly active antiretroviral therapy (HAART). Three year survival of the whole cohort was 27%. By multivariate analysis, the most important prognostic factors for long term survival, were complete responses to CT, (p < 0.01) and a low international prognostic index (IPI) score for NHL, (p = 0.01). HAART, histologic subtype and CD4 lymphocyte count at diagnosis, did not influence survival. Conclusions: The most important prognostic factors for HIV patients with lymphoma, were achieving CR with CT and low IPI score. Prognosis remains poor, even with HAART therapy.