Expresión inmunohistoquímica del complejo E-caderina-catenina en cáncer gástrico: Relación con variables clínico-morfológicas y sobrevida de pacientes

• Pablo Guzmán G ^[1] ; Juan Araya O ^[1] ; Miguel Villaseca H ^[1] ; Iván Roa E ^[1] ; Angélica Melo A ^[1] ; Sergio Muñoz N ^[1] ; Juan Roa S ^[1]
  1. [1] Universidad de La Frontera

     Universidad de La Frontera

     Temuco, Chile

     
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 134, Nº. 8, 2006, págs. 1002-1009
• Idioma: español
• Títulos paralelos:
  • Immunohistochemical expression of the E-cadherin-catenin complex in gastric cancer
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• Resumen

  • Background: The E-cadherin/catenin complex plays an essential role in the control of epithelial differentiation. Abnormal expression in tumors correlates with histological grade, advanced stage and poor prognosis. Aim: To evaluate the expression pattern of E-cadherin/catenin complex in gastric carcinoma and analyze their association with tumor clinicopathological features and patient survival. Material and Methods: Inmunohistochemical staining of E-cadherin, alpha and ß-catenin was performed from paraffin specimens of 65 gastric carcinomas. Results: Abnormal expression of E-cadherin, alpha and ß-catenin was demonstrated in 82%, 85% and 88% of gastric carcinomas, respectively. There was a significant correlation between abnormal expression and Lauren pathological classification and depth of infiltration, but not with tumor stage, positive lymph node metastases and survival. Conclusion: Abnormal expression of E-cadherin, alpha and ß-catenin occurs frequently in gastric carcinoma and correlates with histological grade (Rev Méd Chile 2006; 134: 1002-9).