TRAPS, un síndrome autoinflamatorio: Casos cínicos

• Manuel Alvarez-Lobos ^[1] ; Bessie Hunter ^[2] ; Colomba Cofré ^[2] ; Carlos Benítez ^[1] ; Eduardo Talesnik ^[3] ; Mauricio Oyarzo ^[4] ; Juan I Aróstegui ^[5] ; Jordi Yagüe ^[5]
  1. [1] Pontificia Universidad Católica de Chile

     Pontificia Universidad Católica de Chile

     Santiago, Chile

     
  2. [2] Hospital Luis Calvo Mackenna

     Hospital Luis Calvo Mackenna

     Santiago, Chile

     
  3. [3] P Universidad Católica de Chile Escuela de Medicina Reumatología
  4. [4] P Universidad Católica de Chile Escuela de Medicina Anatomía Patológica
  5. [5] Hospital Clínico de Barcelona Departamento de Inmunología

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 134, Nº. 12, 2006, págs. 1558-1561
• Idioma: español
• Títulos paralelos:
  • Tumor necrosis factor receptor associated periodic syndrome (TRAPS): Report of two cases
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• Resumen

  • Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disorder associated to a mutation of the Tumor Necrosis Factor Receptor 1 (TNFR1) whose clinical presentation consists on recurrent episodes of prolonged fever, abdominal pain, myalgias, migratory cutaneous erythema, conjunctivitis or periorbitary edema. The diagnosis is confirmed by genetic analysis of the TNFR1 gene. Its main complication is amyloidosis and the treatment is based on the use of corticosteroids or anti-TNF antibodies. We report a 17 year-old male and 23 year-old female with the syndrome. Both cases had heterozygous mutations of the TNFR1 gene, C30R in the first case and T50M in the second case