Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr

• Alejandro Corvalán R ^[1] ; Suminori Akiba ^[3] ; María Teresa Valenzuela B ^[2] ; Miguel Angel Cumsille G ^[2] ; Chihaya Koriyama ^[3] ; Jorge Argandoña C ^[4] ; Claudia Backhouse E ^[4] ; Matilde Bal C ^[2] ; Fernando Mena U ^[5] ; Mariana Palma V ^[4] ; Yoshito Eizuru ^[3]
  1. [1] Pontificia Universidad Católica de Chile

     Pontificia Universidad Católica de Chile

     Santiago, Chile

     
  2. [2] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  3. [3] Universidad de Kagoshima Facultad de Medicina Departamento de Salud Pública y Centro de Enfermedades Virales Crónicas
  4. [4] Hospital Clínico San Borja Arriarán Instituto Chileno Japonés de Enfermedades Digestivas
  5. [5] Hospital Max Peralta Departamento de Patología

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 133, Nº. 7, 2005, págs. 753-760
• Idioma: español
• Títulos paralelos:
  • Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus
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• Resumen

  • Background: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. Aim: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. Material and methods: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus. Results: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57). Conclusions: Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr