Identificación de subtipos B y F de VIH-1 en pacientes chilenos

• Maritza Ríos V ^[1] ; Carola Villanueva C ^[1] ; Carolina San Martín ^[1] ; Eugenio Ramírez V ^[1]
  1. [1] Instituto de Salud Pública Subdepartamento Virología Centro Nacional de Referencia del SIDA
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 131, Nº. 7, 2003, págs. 711-718
• Idioma: español
• Títulos paralelos:
  • Identification of B and F human immunodeficiency virus subtypes in Chilean patients
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• Resumen

  • Background: Type I human immunodeficiency virus (HIV) is characterized by a great genetic variability. There are three groups of virus throughout the world: O, N and M. Group M is responsible for AIDS pandemic and is subdivided in 9 genetic subtypes. Most viral strains in South America are subtype B. Aim: To determine the frequency of HIV subtypes in Chilean patients. Material and methods: Genetic analysis of C2-V3-C3 region of the gene env in HIV strains coming from 77 Chilean subjects infected by different means. DNA heteroduplex mobility assay was used to determine HIV subtypes. Results: Sixty eight cases were infected with subtype B (88.3%) and nine cases were infected with subtype F (11.7%). Conclusions: Subtype B is the predominant HIV in Chile, but subtype F is also present (Rev Méd Chile 2003; 131: 711-8)