Elementos morfológicos pronósticos en el cáncer de la vesícula biliar

• Iván Roa E ^[1] ; Xabier de Aretxabala U ^[1] ; Juan C Araya O ^[1] ; Miguel Villaseca H ^[1] ; Juan Roa S ^[1] ; TM Gilda Ibacache S ^[1] ; Luis Burgos S ^[1] ; Sergio Muñoz N ^[1]
  1. [1] Universidad de La Frontera

     Universidad de La Frontera

     Temuco, Chile

     
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 130, Nº. 4, 2002, págs. 387-395
• Idioma: español
• Títulos paralelos:
  • Morphological prognostic factors in gallbladder cancer
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• Resumen

  • Background: The exact survival rates and prognostic factors of gallbladder cancer are still incompletely known. Aim: To report the actuarial survival of patients with gallbladder cancer. Material and methods: Six hundred thirty seven women, aged 59 years old as a mean and 108 men, aged 64 years old as a mean, with gallbladder cancer are reported. Patients were followed for up to 150 months. Results: Two hundred twenty four patients had an early and 521 had an advanced carcinoma. Overall survival was 38% at ten years. Sex or ethnic origin did not influence survival. Early tumors had a 92% survival at 10 years whereas the survival of advanced tumors was 16% at 5 years. Subserous tumors had a 5 years survival of 32% whereas serous tumors had a 5 years survival of 11%. Well-differentiated advanced tumors had a significantly better survival than moderately or poorly differentiated tumors. Vascular or lymphatic infiltration was also associated to a lower survival. All patients with advanced tumors and vascular infiltration died before 5 years. Conclusions: Tumor infiltration and differentiation degree were the most important prognostic independent factors in gallbladder cancer (Rev Méd Chile 2002; 130: 387-395)