Resumen de Antifungal and antibacterial activity of diterpenes isolated from wood extractables of chilean podocarpaceae

José Becerra, C. Flores, J. Mena, P. Aqueveque, J. Alarcón, M. Bittner, V. Hernández, M. Hoeneisen, Eduardo Ruiz, Mario Silva

• español

  Diez diterpenos, ferruginol (1a), hinokiol (1b), hinokione (1c), totarol (2a), totarodiol (2b), totarolone (2c), abietatriene (3), 6,7-dehydroferruginol (4), isopimarol (5) and acetylferruginol (6), fueron aislados desde la madera y corteza de cuatro especies de la familia Podocarpaceae. La estructura de estos compuestos fue determinada mediante métodos espectroscópicos. Se determinó la actividad antimicrobiana de siete de estos compuestos frente a las bacterias: Bacillus brevis, B. subtilis, Escherichia coli, Micrococcus luteus, Providencia sp., Pseudomonas sp., Shigella sp., Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes y sobre los hongos Aspergillus sp., Fusarium fujikuroi, F. ciliatum, Mucor miehei, Nematospora coryli, Paecilomyces variotii and Penicillium notatum. Seis de estos diterpenos exhibieron actividad antibacteriana y cinco antifúngica

• English

  Ten diterpenos, ferruginol (1a), hinokiol (1b), hinokione (1c), totarol (2a), totarodiol (2b), totarolone (2c), abietatriene (3), 6,7-dehydroferruginol (4), isopimarol (5) and acetylferruginol (6), were isolated from wood and bark of four Chilean species of Podocarpaceae. The structures of these compounds were determined by spectroscopic methods. The antimicrobial activities of seven of these compounds against the bacteria: Citrobacter sp., Bacilus subtillis, B. brevis, Escherichia coli, Micrococcus luteus, Shigella sp., Streptococcus pyogenes, Enterococcus faecalis, Providencia sp., Staphylococcus aureus, Proteus mirabilis, Salmonella thyphymurium, Pseudomonas sp. and on the fungi Aspergillus sp., Fusarium fujikuroi, F. ciliatum, Mucor miehei, Nematospora coryli, Paecilomyces variotii and Penicillium notatum , were determined. Six of these diterpenes exhibit antibacterial activity and five antifungal activities