Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents

• Katharinne I Moraes de Carvalho ^[1] ; Hélio B Fernandes ^[1] ; Flávia D Frota Machado ^[1] ; Irisdalva S Oliveira ^[1] ; Francisco A Oliveira ^[1] ; Paulo Humberto M Nunes ^[1] ; Julianeli T Lima ^[2] ; Jackson R G Silva Almeida ^[2] ; Rita C Meneses Oliveira ^[2]
  1. [1] Center for Research on Medicinal Plants
  2. [2] University of San Francisco Valley Pharmaceutical Sciences Collegiate
• Localización: Biological Research, ISSN-e 0717-6287, ISSN 0716-9760, Vol. 43, Nº. 4, 2010, págs. 459-465
• Idioma: inglés
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• Resumen

  • This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75 %), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.