Comparing the survival rates of patients with stage IIIC endometrial cancer undergoing sandwich therapy to those undergoing sequential chemotherapy and radiotherapy: a meta‑analysis

• Meng Meng Zhang ^[1] ; Yu Kun Chen ^[1] ; Li Shi ^[1] ; Jing Ma ^[1] ; Jing De Jia ^[1] ; Xi Wa Zhao ^[1]
  1. [1] Hebei Medical University

     Hebei Medical University

     China

     
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 6, 2024, págs. 1329-1337
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen
  • español

    Overall survival; Sandwich therapy; Sequential therapy; Stage IIIC endometrial cancer ; Toxicity

  • English

    Background The use of additional treatment after surgery for stage IIIC endometrial cancer (EC) according to the Federation of Gynecology and Obstetrics (FIGO) is still a topic of discussion. This meta-analysis examined the efects of sandwich treatment and sequential treatment on the survival of individuals diagnosed with stage IIIC EC.

    Methods We examined the literature from various databases regarding the overall survival (OS) and adverse efects of the two additional therapies following surgery in individuals diagnosed with stage IIIC EC. Revman 5.4.1 was utilized to combine hazard ratios (HR) and their corresponding 95% confdence intervals (95% CI) for OS and toxicities.

    Results The fndings comprised of fve retrospective investigations involving a combined total of 800 individuals. The patients who underwent sandwich treatment did not demonstrate a notable improvement in survival rates over a period of 3 years. Upon eliminating the impact of extensive samples, it was discovered that sandwich therapy exhibited a superior 5-year overall survival compared to patients receiving sequential therapy. The efectiveness of sandwich therapy was superior to sequential therapy in terms of a 3-year OS for non-endometrioid histology, although the outcome did not reach statistical signifcance. The toxicities of both treatments were similar.

    Conclusions In terms of long-term survival, sandwich therapy was found to be more advantageous than sequential therapy for patients with stage IIIC EC, with no signifcant disparity observed in the 3-year OS and toxicities between the two treatments.

    Sandwich therapy exhibited a tendency towards improved efectiveness in patients with histology other than endometrioid.