Cardiovascular comorbidities and their prognostic value in small cell lung cancer patients with chemoradiotherapy

• Hanyang Liang ^[1] ; Tianjie Wang ^[1] ; Dong Liu ^[1] ; Hao Wang ^[1] ; Zhengqing Ba ^[1] ; Ying Xiao ^[1] ; Yilu Liu ^[1] ; Jiansong Yuan ^[1] ; Weixian Yang ^[1]
  1. [1] State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing 100037, China
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 6, 2024, págs. 1348-1356
• Idioma: inglés
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• Resumen

  • Background Small cell lung cancer (SCLC) is an extremely malignant subtype of lung cancer because of its high potential for metastases. Cardiac invasion of SCLC is a serious concern that may lead to systemic embolism or tract obstruction. It has aroused much concern that cardiovascular comorbidities may signifcantly afect the survival of SCLC patients and their treatment decisions.

    Methods We consecutively recruited 772 small cell lung cancer (SCLC) patients between January 2011 and December 2018 from 4 cancer specialty hospitals in China. Only newly diagnosed primary cancer inpatients were included. Univariable and multivariable adjusted Cox proportional hazard models were conducted to evaluate the risk factors associated with mortality. Hazard ratios (HRs) for mortality and corresponding 95% confdence intervals (95% CIs) were calculated.

    Results The prevalence of cardiovascular diseases (CVDs) was 34.6% in all SCLC patients. Log-rank analysis presented statistically signifcant diferences in median survival time (MST) between patients with CVD and without CVD in all SCLC patients (9.0 months vs. 15.0 months, P=0.005) and patients with chemotherapy only (12.0 months vs. 18.0 months, P=0.048). Pericardial efusion (HR 1.671, 95% CI 1.082–2.580, P=0.021) and heart failure (HR 1.752, 95% CI 1.290–2.379, P<0.001) were independent risk factors associated with mortality in all SCLC patients. VTE is related to poorer prognosis in patients with chemotherapy only (HR 5.558, 95% CI 1.335–23.135, P=0.018) and chemoradiotherapy (HR 3.057, 95% CI 1.270–7.539, P=0.013).

    Conclusions Comprehensive management of CVD comorbidities is of vital importance for the long-term prognosis of SCLC patients.