Radiation‑induced changes in gene expression in rectal cancer specimens
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Lily Victoria Sarah Hillson [1] ; Ashley Kathryn McCulloch [1] ; Joanne Edwards [1] ; Sean Michael OCathail [1] ; Campbell Stuart Roxburgh [1] ; Philip David Dunne [2]
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[1] University of Glasgow
University of Glasgow
Reino Unido
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[2] Queen's University Belfast
Queen's University Belfast
Reino Unido
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 6, 2024, págs. 1419-1428
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Purpose The standard-of-care for locally advanced rectal cancer is radiotherapy-based neoadjuvant therapy followed by surgical resection. This article reviews the evidence of molecular changes at the transcriptome level induced through radiotherapy in rectal cancer.
Methods The PubMed search “(radiation OR radiotherapy) cancer (transcriptome OR “gene expression”) rectal” was used. The studies taken forward utilised gene-expression data on both pre-treatment and post-treatment rectal adenocarcinoma biospecimens from patients treated with RT-based neoadjuvant strategies.
Results Twelve publications met the review criteria. There was variation in approaches in terms of design, patient population, cohort size, timing of the post-radiotherapy sampling and method of measuring gene expression. Most of the post-treatment biospecimen retrievals were at resection. The literature indicates a broad upregulation of immune activity through radiotherapy using gene-expression data.
Conclusion Future studies would beneft from standardised prospective approaches to sampling to enable the inclusion of timepoints relevant to the tumour and immune response.
