An epigenetic manifestation of Alzheimer's disease: DNA methylation

• Boyi Feng ^[2] ; Junli Zheng ^[2] ; Ying Cai ^[3] ; Yaguang Han ^[1] ; Yanhua Han ^[1] ; Jiaqi Wu ^[2] ; Jun Feng ^[2] ; Kai Zheng ^[2]
  1. [1] Heilongjiang University of Chinese Medicine

     Heilongjiang University of Chinese Medicine

     China

     
  2. [2] Department of Chronic Disease, Longhua District Center for Chronic Disease Control/Mental Health, Shenzhen, Guangdong, China
  3. [3] Public Health Service Center, Bao’an District, Shenzhen, Guangdong, China

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• Localización: Actas españolas de psiquiatría, ISSN 1139-9287, Vol. 52, Nº. 3, 2024, págs. 365-374
• Idioma: inglés
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• Resumen

  • Alzheimer's disease (AD), the most common form of dementia, has a complex pathogenesis. The number of AD patients has increased in recent years due to population aging, while a trend toward a younger age of onset has arisen, imposing a substantial burden on society and families, and garnering extensive attention. DNA methylation has recently been revealed to play an important role in AD onset and progression. DNA methylation is a critical mechanism regulating gene expression, and alterations in this mechanism dysregulate gene expression and disrupt important pathways, including oxidative stress responses, inflammatory reactions, and protein degradation processes, eventually resulting in disease. Studies have revealed widespread changes in AD patients' DNA methylation in the peripheral blood and brain tissues, affecting multiple signaling pathways and severely impacting neuronal cell and synaptic functions. This review summarizes the role of DNA methylation in the pathogenesis of AD, aiming to provide a theoretical basis for its early prevention and treatment.