Resumen de Antifungal potential and chemical composition of Tagetes lunulata Ort. essential oil for the control of Trichophyton rubrum Malmsten

Mitzi Irais Rodríguez Juárez, Enrique Arjona Suarez, Jorge Cadena Íñiguez, Brenda Karina Guevara Olivar, Lucero del Mar Ruiz Posadas

• The essential oils of aromatic and medicinal plants are an important resource used to control several health conditions; however, information about their composition and antimicrobial activity is scarce. This study used a gas chromatography-mass spectrometry (GC-MS) to analyze the composition of the essential oil (EO) of Tagetes lunulata Ort., a Mexican endemic plant, known as wild cempaxúchitl. The major components of the EO include: verbenone (47.17%), α-pinene (10.93%), 1,1,1-Trifluoro-2-hexanone (9.63%), β-caryophyllene (6.10%), germacrene-D (4.99%), L-verbenone (4.89%), and E-tagetone (4.44%). The disk agar diffusion method was used to evaluate the antimicrobial activity of T. lunulata against Trichophyton rubrum (athlete's foot). A significant antimicrobial activity was observed with a ≥60% EO concentration. The dilution method was used to determine the minimum inhibitory concentration (MIC): 200 μg ml-1. The T. lunulata EO recorded a strong antimicrobial activity against T. rubrum; therefore, it is a natural alternative for the control of natural antifungals.