Comparison of a daily and alternate-day photobiomodulation protocol in the prevention of oral mucositis in patients undergoing radiochemotherapy for oral cancer: a triple-blind, controlled clinical trial

• Flávia Marília Azeredo de Oliveira ^[2] ; Marcela Maria Fontes Borges ^[1] ; Cássia Emanuella Nóbrega Malta ^[1] ; José Fernando Bastos de Moura ^[3] ; Clarissa Pessoa Fernandes Forte ^[2] ; Jennifer Vianna Barbosa ^[2] ; Paulo Goberlânio de Barros Silva ^[1] ; Thinali Sousa Dantas ^[2]
  1. [1] Universidade Federal do Ceará

     Universidade Federal do Ceará

     Brasil

     
  2. [2] Department of Dentistry, Unichristus, Fortaleza, Ceará, Brazil
  3. [3] Hospital Haroldo Juaçaba, Ceará Cancer Institute, Fortaleza, Ceará, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 29, Nº. 3 (May), 2024
• Idioma: inglés
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  • Preventive Photobiomodulation Therapy (PBMT) significantly reduces oral mucositis (OM) severity in patients undergoing Radiochemotherapy (RCT) for the treatment of oral cancer, but daily applications generate cost, overload the dental team, and reduce the number of patients assisted.To evaluate the effectiveness of two PBMT protocols in preventing OM in patients undergoing RCT for oral cancer.

    16 patients diagnosed with oral cancer undergoing RCT were included, equally divided into two groups: a group treated daily with PBMT, and another group also submitted to daily treatment, however, performing the application of PBMT every three days, interspersed with a simulation of PBMT (placebo). A red laser was used (~660 nm), 0.1W power, 1J of energy applied per point, 9 points per area (labial mucosa, buccal mucosa, lateral borders of the tongue, body of the tongue, and floor of the mouth) from the beginning of RCT until the end of the oncological treatment. Daily assessments were performed regarding OM scores, the World Health Organization (WHO) pain scale, and the visual analog scale (VAS). Weight, salivary flow (SGAPP), OHIP-14, and DMFT were evaluated on the initial and final days of RT. OM incidence and clinical data were compared by Pearson's chi-square test or Fisher's exact test. Pain and other scale scores were compared using the Mann-Whitney and Friedman/Dunn tests (SPSS v20.0 p<0.05).

    In the group with PBMT on alternate days, there was an increase in the frequency of grade 2 and grade 3 oral mucositis and an increased risk of grade 2 oral mucositis, in addition to higher mean pain scores and greater reduction in salivary flow.

    The daily PBMT protocol proved more effective in controlling the frequency and severity of OM, pain, and salivary flow.