Females with Breast Development before Three Years of Age

• Paul B. Kaplowitz ^[1] ; Peter A. Lee ^[1]
  1. [1] Division of Endocrinology, Children’s National Hospital, George Washington School of Medicine and Health Sciences, 111 Michigan Avenue Northwest, Washington, DC 20010, USA b Division of Pediatric Endocrinology, Penn State School of Medicine, Milton S. Hershey Medical Center, 500 University Avenue, Hershey, PA 17033, USA
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 53, Nº. 2, 2024, págs. 195-201
• Idioma: inglés
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• Resumen

  • Breast development in a girl 3 years of age or younger is a commonly encountered scenario. Nearly all of these cases will either regress or fail to progress during follow-up, confirming a diagnosis of premature thelarche (PT). Studies show that these girls will have onset of true puberty and menses at a normal age. The authors present evidence that laboratory testing, particularly basal and gonadotropin hormone-releasing hormone -stimulated gonadotropin levels, will show overlap between girls with PT and the rare patients with the onset of central precocious puberty before age 3, mainly of whom have hypothalamic hamartomas.