Diagnosis of Central Precocious Puberty

• Kanthi Bangalore Krishna ^[1] ; Lawrence A. Silverman ^[2]
  1. [1] Division of Pediatric Endocrinology and Diabetes, UPMC Childrens Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
  2. [2] Division of Pediatric Endocrinology, Goryeb Children’s Hospital, Atlantic Health System, 100 Madison Avenue, Morristown, NJ 07960, USA
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 53, Nº. 2, 2024, págs. 217-227
• Idioma: inglés
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• Resumen

  • A thorough history and physical examination including Tanner staging and growth assessments can guide differential diagnosis and aid in the evaluation of precocious puberty. Basal luteinizing hormone levels measured using a highly sensitive assay can be helpful in diagnosing central precocious puberty (CPP). Brain MRI is indicated with males diagnosed with CPP and females under the age of 6 with CPP. As more information becomes available regarding the genetic etiologies of CPP, genetic testing may preclude the need for imaging studies and other hormonal testing, especially in familial cases.