Resumen de Implicación de la Sintasa inducible de óxido nítrico (INOS) en la cardiopatía isquémica (CAI)
M. Via, E. Esteban, E. González Pérez, N. Rodón, J. Santamaría, Xavier Pintó Sala, E. Domingo, N. Valveny, Antonio López Alomar, P. Moral
Molecular variation in nitric oxide synthases (NOS) has been intensively studied in relation to cardiovascular system. Moreover, a previous study has shown different NOS molecular variation patterns in the Mediterranean area. A genetic association study has been performed between three polymorphisms in the endothelial nitric oxide synthase (eNOS or NOS3) and two in the inducible nitric oxide synthase (iNOS or NOS2) in a 98 nuclear families sample with one individual affected by ischaemic heart disease (TDT) and revealed associations between the 9-repeats allele of the iNOS pentanucleotide (P = 0.008) and the 13 and 18 alleleles of the eNOS dinucleotide (P = 0.023 abd P = 0.013). These data support the important role of eNOS in genetic susceptibility to IHD, and revealed a potential role of iNOS gene in the susceptibility to this disease.
