Epigenetics in Periodontics
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María Eugenia Paredes Herrera, María Eugenia Paredes Herrera
[1]
;
Miranda Rosero, Oswaldo Damián
;
Tobar Peñaherrera, Adriana Nicole
[1]
;
Salazar Durán, María de los Ángeles
[1]
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[1] Universidad Regional Autónoma de Los Andes
Universidad Regional Autónoma de Los Andes
Ambato, Ecuador
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- Localización: Interamerican Journal of Health Sciences (IJHS), ISSN-e 2953-3724, Nº. 4, 2024
- Idioma: inglés
- Enlaces
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Resumen
Background: periodontitis is a pathology characterized by the destruction of dental support tissue, in its worst scenario it can cause the loss of the dental organ; Its etiological factor is periodontopathogenic bacteria, however, this is a multifactorial disease, that is, not only environmental factors are involved but also genetic factors that are responsible for modulating the progression of periodontal disease. Not all patients will have the same susceptibility to developing Periodontitis since basically this will depend on the immunity of the host and its genetic code. Objective: to present the epigenetic mechanisms that have been applied in the field of Periodontics in order that these studies lead to the discovery of new regulatory treatments that offer to be an alternative to control inflammation in Periodontitis, that is, based on the findings already exposed in the future it is estimated that they can be translated into clinical practice. Methods: this article has prepared a compilation and analysis of the literature using the database of Scopus, Pubmed, EBSCO and Cochrane. We included experimental trials, case-control studies, review studies and meta-analyses. Results: Several studies have been presented that facilitate the understanding of the epigenetic mechanisms involved in pathological processes, such as specific biomarkers for certain diseases and genes that regulate inflammatory processes; In addition, it was mentioned that there are inhibitory molecules that allow the modulation of the inflammatory process of the host
