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Trends in prescribing montelukast in patients with asthma in real-life: Results from the Turkish adult asthma registry

  • Şengül Beyaz [10] ; Münevver Erdinç [1] ; Serhat Hayme [11] ; Ayşe Feyza Aslan [2] ; Ömür Aydın [3] ; Derya Gökmen [3] ; Gözde Köycü Buhari [12] ; Zeynep Çelebi Sözener [3] ; Bilun Gemicioğlu [13] ; Ismet Bulut [14] ; Cihan Örçen [14] ; Seçil Kepil Özdemir [15] ; Metin Keren [4] ; Ebru Damadoğlu [4] ; Tuğçe Yakut [16] ; Ayşe Füsun Kalpaklıoğlu [17] ; Ayşe Baccıoğlu [17] ; Sümeyra Alan Yalım [17] ; Insu Yılmaz [5] ; Ilkay Koca Kalkan [12] ; Mehmet Atilla Uysal [18] ; Elif Yelda Özgün Niksarlıoğlu [18] ; Ali Fuat Kalyoncu [4] ; Gül Karakaya [4] ; Müge Erbay [4] ; Sibel Naycı [6] ; Fatma Merve Tepetam [14] ; Aslı Akkor Gelincik [2] ; Hülya Dirol [7] ; Özlem Göksel [1] ; Selen Karaoğlanoğlu [8] ; Ferda Öner Erkekol [19] ; Sacide Rana Isık [20] ; Füsun Yıldız [21] ; Yasemin Yavuz [3] ; Dilek Karadoğan [22] ; Nurgül Bozkurt [7] ; Ümmühan Şeker [10] ; Ipek Kıvılcım Oğuzülgen [10] ; Ilknur Başyiğit [21] ; Serap Argun Barış [21] ; Elif Yılmazel Uçar [10] ; Tuba Erdoğan [10] ; Mehmet Polatlı [10] ; Dane Ediger [10] ; Fatma Esra Günaydın [10] ; Murat Türk [5] ; Leyla Pür [10] ; Zeynep Yeğin Katran [14] ; Yonca Sekibağ [13] ; Enes Furkan Aykaç [13] ; Dilşad Mungan [3] ; Özcan Gül [3] ; Ali Cengiz [3] ; Bülent Akkurt [15] ; Şeyma Özden [14] ; Semra Demir [2] ; Derya Ünal [2] ; Ali Can [2] ; Reyhan Gümüşburun [1] ; Gülhan Boğatekin [1] ; Hatice Serpil Akten [1] ; Sinem İnan [1] ; Aliye Candan Öğüş [7] ; Murat Kavas [14] ; Demet Polat Yuluğ [10] ; Mehmet Erdem Çakmak [4] ; Saltuk Buğra Kaya [4] ; Gülistan Alpagat [17] ; Eylem Sercan Özgür [6] ; Oğuz Uzun [10] ; Şule Taş Gülen [10] ; Gülseren Pekbak [10] ; Deniz Kızılırmak [10] ; Yavuz Havlucu [10] ; Halil Dönmez [10] ; Bahar Arslan [5] ; Gülden Paçacı Çetin [5] ; Şadan Soyyiğit [19] ; Bilge Yılmaz Kara [22] ; Gülden Paşaoğlu Karakış [10] ; Adile Berna Dursun [23] ; Reşat Kendirlinan [24] ; Ayşe Bilge Öztürk [25] ; Can Sevinç [9] ; Gökçen Ömeroğlu Şimşek [9] ; Öznur Abadoğlu [26] ; Pamir Çerçi [27] ; Taşkın Yücel [4] ; İrfan Yorulmaz [3] ; Zahide Çiler Tezcaner [3] ; Emel Çadallı Tatar [28] ; Ahmet Emre Süslü [4] ; Serdar Özer [4] ; Engin Dursun [29] ; Arzu Yorgancıoğlu [30] ; Gülfem Elif Çelik [3]
    1. [1] Ege University

      Ege University

      Turquía

    2. [2] Istanbul University

      Istanbul University

      Turquía

    3. [3] Ankara University

      Ankara University

      Turquía

    4. [4] Hacettepe University

      Hacettepe University

      Turquía

    5. [5] Erciyes University

      Erciyes University

      Turquía

    6. [6] Mersin University

      Mersin University

      Turquía

    7. [7] Akdeniz University

      Akdeniz University

      Turquía

    8. [8] Ordu University

      Ordu University

      Turquía

    9. [9] Dokuz Eylül University

      Dokuz Eylül University

      Turquía

    10. [10] Clinic of Immunology and Allergy Diseases, Ankara Bilkent City Hospital, Ankara, Turkey
    11. [11] Department of Biostatistics and Health Informatics, Erzincan Binali Yildirim University School of Medicine, Erzincan, Turkey
    12. [12] Department of Immunology and Allergy, Ankara Ataturk Sanatoryum Training and Research Hospital, University of Health Sciences, Ankara, Turkey
    13. [13] Department of Pulmonary Diseases, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey
    14. [14] Department of Immunology and Allergy, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
    15. [15] Department of Chest Diseases, Division of Allergy and Immunology, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, University of Health Sciences, Izmir, Turkey
    16. [16] Clinic of Immunology and Allergic Diseases, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakır, Turkey
    17. [17] Department of Allergy and Immunology, Faculty of Medicine, Kirikkale, Kirikkale University, Turkey
    18. [18] Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
    19. [19] Clinic of Immunology and Allergic Diseases, Ankara Bilkent City Hospital, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey
    20. [20] Adult Allergy and Immunology Department, American Hospital, Istanbul, Turkey
    21. [21] Department of Pulmonary Diseases, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
    22. [22] Department of Chest Diseases, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey
    23. [23] Department of Chest Diseases, Division of Allergy and Immunology, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey
    24. [24] Clinic of Immunology and Allergic Diseases, Izmir Ataturk Training and Research Hospital, Izmir, Turkey
    25. [25] Department of Allergy and Immunology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey
    26. [26] Private Immunology and Allergy Clinic, Istanbul, Turkey
    27. [27] Clinic of Immunology and Allergic Diseases, Van Regional Training and Research Hospital, Van, Turkey
    28. [28] Department of Otolaryngology, Etlik City Hospital, University of Health Sciences, Ankara, Turkey
    29. [29] Department of Otorhinolaryngology, Faculty of Medicine, Lokman Hekim University, Ankara, Turkey
    30. [30] Department of Pulmonology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey
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  • Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 53, Nº. 1, 2025, págs. 12-25
  • Idioma: inglés
  • Enlaces
  • Resumen

    • Montelukast, a leukotriene receptor antagonist (LTRA) approved for the treatment of asthma and allergic rhinitis, is widely used, though real-world data on its application in asthma management remain limited. This registry-based study evaluated the use of montelukast in adult asthma patients, examining demographic and disease characteristics, asthma control status, asthma phenotypes, presence of atopy, and treatment regimens. Among 2053 patients analyzed, 61.76% (n = 1268; mean age: 46.2 ± 14.3 years), predominantly females (~76%), received montelukast. Montelukast users showed higher rates of allergic rhinitis (P < 0.001), hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) (P = 0.008), and chronic rhinosinusitis (P = 0.008). Montelukast group also had higher atopy and total IgE levels and tended to be more eosinophilic. Montelukast was commonly preferred in allergic, eosinophilic, NSAID-exacerbated respiratory disease, and severe asthma phenotypes (P < 0.001). Patients receiving Steps 4 and 5 treatments are more likely to be prescribed montelukast (P < 0.001). Montelukast usage was higher among patients with uncontrolled asthma [ACT< 20 (OR:1.29, 95%CI:1.052–1.582, P = 0.014)]. In addition, logistic regression analyses identified the main factors associated with increased montelukast use as; female gender (OR:1.33, 95%CI:1.041–1.713, P = 0.02), presence of atopy (OR:1.46, 95%CI:1.157–1.864, P = 0.002), comorbid allergic rhinitis (OR:2.12, 95%CI:1.679–2.293, P < 0.001), and severe asthma (OR:2.18, 95%CI:1.712–2.784, P < 0.001). These findings reveal that montelukast use is prevalent among asthma patients, particularly in females, middle-aged adults, and those with comorbid allergic rhinitis, uncontrolled asthma, or specific asthma phenotypes, underscoring the factors that influence its prescription in asthma management.

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