Breast cancer epidemiology: mammographic screening and molecular subtypes

• Autores: Montse Puig Vives
• Directores de la Tesis: Rafael Marcos Gragera (dir. tes.), Marc Sáez Zafra (dir. tes.)
• Lectura: En la Universitat de Girona ( España ) en 2015
• Idioma: inglés
• Tribunal Calificador de la Tesis: Josep Maria Borràs Andrés (presid.), Joan Brunet i Vidal (secret.), Maria Sala Serra (voc.)
• Materias:
  • Ciencias médicas
    • Epidemiología
    • Patología
      • Oncología
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • The aim of this thesis is to carry out an in-depth study of various aspects of breast cancer epidemiology. Firstly, we have confirmed that DCIS incidence in Girona has increased over recent decades. Proportions of screen-detected cancers, interval cancers and non-screen-detected cancers during the start-up phase of the mammographic screening programme were found to be 42.2%, 5.8% and 52.2%, respectively. Secondly, we have found that luminal A-like was the most frequent subtype associated with the best survival rate, while triple-negative breast cancer was related to the lowest survival rate. Importantly, we have concluded that breast cancer molecular subtype defined by IHC biomarkers provides prognostic value, regardless of age, tumour size, histological grade, lymph node involvement and method of detection. Finally, we have demonstrated that method of detection also provides prognostic value regardless of age, tumour size, histological grade, lymph node involvement and breast cancer molecular subtype defined by IHC biomarkers.