Managanese and dicopper complexes for bioinspired oxidation reactions: catalytic and mechanistic studies on C-H and C=C oxidations
- Autores: Isaac García Bosch
- Directores de la Tesis: Miquel Costas Salgueiro (dir. tes.), Xavier Ribas Salamaña (dir. tes.)
- Lectura: En la Universitat de Girona ( España ) en 2011
- Idioma: inglés
- Tribunal Calificador de la Tesis: Peter Comba (presid.), Mª de los Ángeles Martínez Lorente (secret.), Manuel García Basallote (voc.), Rosa María Llusar Barelles (voc.), Martin Albrecht (voc.)
- Materias:
- Enlaces
- Tesis en acceso abierto en: TDX
- Resumen
Enzymes are high-weight molecules which catalyze most of the metabolic processes in living organisms. Very often, these proteins contain one or more 1st row transition metal ions in their active center (Fe, Cu, Co, Mn, Zn, etc.), and are known as metalloenzymes or metalloproteins. Among these, metalloenzymes that activate molecular oxygen and use it as terminal oxidant stand out because of the wide range of catalyzed reactions and their exquisite selectivity. In this PhD dissertation we develop low-weight synthetic bioinspired complexes that can mimic structural and/or functional features of the active center of oxigenases. In the first part, we describe the use of unsymmetric dinuclear Cu complexes which are capable of performing the oxidation of phenols and phenolates in a analogous manner of the tyrosinase protein. In the second part, we describe the use of mononuclear manganese complexes in the oxidation of alcanes and alquenes.
