Estudio de la rigidez arterial en arteria carótida y depósito tisular de hierro mediante resonancia magnética: relación con los factores de riesgo asociados al síndrome metabólico

• Autores: Gerard Blasco Solã
• Directores de la Tesis: Wifredo Ricart Angel (dir. tes.), Simone Balocco (dir. tes.), José Manuel Fernández Real Lemos (dir. tes.)
• Lectura: En la Universitat de Girona ( España ) en 2015
• Idioma: español
• Tribunal Calificador de la Tesis: José María Alústiza Echeverría (presid.), Joan Vendrell Ortega (secret.), Tomás Alarcón Cor (voc.)
• Materias:
  • Física
    • Física del estado sólido
      • Resonancia magnética
  • Ciencias médicas
    • Medicina interna
      • Endocrinología
    • Patología
      • Patología cardiovascular
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • The aim is to demonstrate the utility of magnetic resonance (MR) for identifying subclinical changes associated with the metabolic syndrome (MS) that contribute to increased cardiometabolic risk. The effect of MS on arterial stiffness and tissue iron load were evaluated using MR in subjects with the MS and control subjects. Arterial stiffness was higher in subjects with MS than in those without. The components contributing independently to an increased pulse wave velocity were hypertension and hypertriglyceridemia. Increased iron concentration was significantly detected at the liver and brain in obese subjects. Obesity-associated brain iron overload was correlated with worse cognitive performance. Obesity and insulin resistance were found as the main factors that contribute to tissue iron deposition. In conclusion, this thesis demonstrates the utility of MR to evaluate subclinical risk changes associated with the MS in subjects without diabetes or ischemic disease