Synthesis of unusual alpha-amino acids and study of the effect of their incorporation into antimicrobial peptides. Total synthesis of biactive marine natural products and analogues thereof

• Autores: Abdellatif El Marrouni El Ghzaoui
• Directores de la Tesis: Janine Cossy (dir. tes.), Montserrat Heras Corominas (dir. tes.)
• Lectura: En la Universitat de Girona ( España ) en 2012
• Idioma: inglés
• Tribunal Calificador de la Tesis: Jean Martinez (presid.), Anna Pla Quintana (secret.), Maria Isabel Matheu Malpartida (voc.), Lidia Feliu Soley (voc.), Gwilherm Evano (voc.)
• Materias:
  • Química
    • Bioquímica
      • Aminoácidos
      • Péptidos
    • Química orgánica
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • The principle theme of this thesis was the synthesis of bioactive compounds. To this end, this work was focus on two main projects. The first one, which was carried out in the Department of Chemistry of the University of Girona under the supervision of Dr Montserrat Heras, concerned the synthesis of new unnatural amino acids bearing a pyrimidine ring within their side chain for incorporation into the antimicrobial peptide BP100 following a rational design in order to improve its biological profile. On the other hand, the second chapter of this thesis was developed in collaboration with the Laboratoire de Chimie Organique (ESPCI-ParisTech, Paris, France) under the guidance of Pr Janine Cossy and Dr Arseniyadis. This chapter was centered on the total synthesis of three marine natural products with complex structures and interesting biological activities: acremolide B, (–) bitungolide F and lyngbouilloside.