Progesterone-treatment in a model of Retinitis Pigmentosa: the rd1 mice
- Autores: Violeta Sánchez Vallejo
- Directores de la Tesis: Francisco Javier Romero Gómez (dir. tes.), María Miranda Sanz (dir. tes.)
- Lectura: En la Universidad CEU Cardenal Herrera ( España ) en 2015
- Idioma: español
- Tribunal Calificador de la Tesis: María Inmaculada Almansa Frías (presid.), Francisco Javier Sancho Pelluz (secret.), Jaime Salcedo Dominguez (voc.)
- Materias:
- Enlaces
- Tesis en acceso abierto en: Repositorio Institucional CEU
- Resumen
The oral administration of progesterone in the early phases of RP under the conditions used in the present study had a direct and positive effect on photoreceptors, rescuing them structurally and functionally in rd1 mice. 1. There is an alteration in glutamate, GSH and GSSG concentrations in the retina of rd1 mice at different post-natal days. 1.1 Glutamate concentration is increased in the retina from rd1 mice compared to the glutamate concentration found in the retina from wt mice. 1.2 GSH concentration is increased in the retina of rd1 mice, immediately after the peak of cell death compared to GSH concentration from wt mice. 1.3 GSSG concentration is increased in the retina of rd1 mice compared to that concentration found in the retina from wt mice. 1.4 There were no changes in Cys concentrations in the retina from rd1 mice compared to those concentrations found in the retina from wt mice. 2. Progesterone treatment delays cell death in an experimental model of RP, the rd1 mouse. 2.1 Progesterone treatment is able to restore the alterations in glutamate concentrations and thiol metabolism observed in the retina of rd1 mice. 2.2 Progesterone oral treatment is able to transiently protect photoreceptors from death in the retina of rd1 mice. 2.3 Progesterone treatment is able to prevent the characteristic gliosis observed in the retina of the rd1 mouse model. 2.4 Oral progesterone treatment is able to improve retinal functionality in rd1 mice.
