Cyclobutane-containing peptides and ureas: synthesis, folding, self-assembling and some biological properties

• Autores: Esther Gorrea Morral
• Directores de la Tesis: Vicenç Branchadell Gallo (dir. tes.), Rosa María Ortuño Mingarro (dir. tes.)
• Lectura: En la Universitat Autònoma de Barcelona ( España ) en 2012
• Idioma: inglés
• Tribunal Calificador de la Tesis: Josep Maria Lluch López (presid.), Jesús Jiménez Barbero (secret.), Norbert Sewald (voc.)
• Materias:
  • Física
    • Física molecular
      • Estructura molecular
  • Química
    • Bioquímica
      • Péptidos
• Enlaces
  • Tesis en acceso abierto en: TESEO
• Resumen

  • Peptides and relative compounds, have been widely used and studied during the past decades. In the present thesis, an enantioselective synthesis and structural study of a variety of cyclobutane-containing beta-peptides and ureas is exposed. By means of experimental and theoretical techniques, their adoption of different folding structures due to the presence of self-assembling properties is described. These properties, in some cases, allowed the preparation of stable gels in organic solvents, which obtaintion was fully studied.

    In addition, the use of solid-phase peptide synthesis strategy was assaied in order to prepare hybrid cyclobutane-proline hexapeptides. Those, were studied as possible cell-penetrating agents.