Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system

• Autores: Agustín Sánchez Temprano
• Directores de la Tesis: Yolanda Pazos Randulfe (dir. tes.), Jesús Pérez Camiña (dir. tes.), José Luis Relova Quinteiro (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2019
• Idioma: inglés
• Tribunal Calificador de la Tesis: Antonio Serrano (presid.), Ángel Jesús Prieto González (secret.), Carmen Conde Muro (voc.)
• Programa de doctorado: Programa de Doctorado en Endocrinología por la Universidad de Santiago de Compostela y la Universidad de Vigo
• Materias:
  • Ciencias de la vida
    • Biología molecular
  • Ciencias médicas
    • Medicina interna
      • Endocrinología
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Peripheral nerve injury is a high-incidence clinical problem, significantly affecting the patient’s life quality and causing an enormous socioeconomic burden. It still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory. Accordingly, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. In this scenario, the present study involves the obestatin/GPR39 system in the improvement of the peripheral nerve repair, by enhancing both neuroprotection and remyelination, and thus the regeneration of the damaged nerve, counteracting the severe loss of function and the atrophy of the innervated muscle. Consequently, obestatin is postulated as a potential therapeutic agent for peripheral nervous system regeneration.