Diskinesia in first-episode schizophrenic patients treated with second generation antipsychotics. Abnormal movements and schizophrenia outcome

• Autores: Carles García Ribera
• Directores de la Tesis: Enric Alvarez Martinez (dir. tes.), María J. Portella (codir. tes.)
• Lectura: En la Universitat Autònoma de Barcelona ( España ) en 2018
• Idioma: español
• Tribunal Calificador de la Tesis: Josep Maria Haro Abad (presid.), Jesús Vicente Cobo Gómez (secret.), Susana Ochoa Güerre (voc.)
• Programa de doctorado: Programa de Doctorado en Psiquiatría por la Universidad Autónoma de Barcelona
• Materias:
  • Ciencias médicas
    • Psiquiatría
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • Many movement abnormalities observed in schizophrenic patients are neglected, especially those in mild and moderate forms or associated to anosognosia. The role of extrapyramidal movements specifically dyskinesia and Parkinsonism as prognostic factor in schizophrenia is not well known. In this prospective work the relationship of dyskinesia and other extrapyramidal symptoms with one-year psychiatric outcome has been studied in a cohort of 112 patients suffering from first episode of the schizophrenia spectrum disorder and treated with Second Generation Antipsychotics. Results showed that the linear regression model of outcome fit early response (p= 0.001), abuse of alcohol (p= 0.026), higher occupational level reached (p= 0.031), younger age at onset (p= 0.033), dyskinetic movements during the first twenty-four week (p= 0.034) and female sex (p= 0.039), but not Parkinsonism during the first eight weeks, as significant variables (adjusted R² 0,416). The direction of the association of dyskinesia with the illness severity was negative. Thirty-two patients showed dyskinesia in the first twenty-four weeks and six patients were diagnosed with tardive dyskinesia during the follow-up of the study (5.3% out of 112 patients in the initial sample, 8.3% out of the 72 patients that completed the follow-up). The potential role of early dyskinetic movements as a window of the dopaminergic system in schizophrenia is postulated.

    Key words: Schizophrenia outcome, dyskinesia, antipsychotic.