Effects of amp-activated kinase modulators on intracellular ca2+ signalling and c. Elegans lifespan

• Autores: Jessica Arias del Val
• Directores de la Tesis: Javier Álvarez Martín (dir. tes.), Mayte Montero (dir. tes.), Rosalba I. Fonteriz García (dir. tes.)
• Lectura: En la Universidad de Valladolid ( España ) en 2018
• Idioma: español
• Tribunal Calificador de la Tesis: María Teresa Alonso Alonso (presid.), Ana Isabel de Cáceres Bustos (secret.), Ricardo Borges Jurado (voc.)
• Programa de doctorado: Programa de Doctorado en Investigación Biomédica por la Universidad de Valladolid
• Materias:
  • Ciencias de la vida
    • Biología humana
• Enlaces
  • Tesis en acceso abierto en: UVADOC
• Resumen

  • AMPK is a key energy homeostasis regulator that coordinates metabolic pathways by balancing the supply of nutrients with energy demand. Current evidence supports the idea that anabolic signalling accelerates aging, while a decrease in nutrient signalling pathways extends longevity. In this way, a pharmacological intervention that mimics a limited availability of nutrients or activates catabolic pathways could extend longevity. Likewise, it is believed that the positive regulation of AMPK would favor a healthy aging.

    As the concepts of energy balance and nutrient-sensitive pathways are considered nowadays key determinants of lifespan, and Ca2+ signalling is tightly related to both of them, the main goal of this thesis is to investigate the relationship between the activity of the AMPK signalling pathway, intracellular Ca2+ signalling and aging in C. elegans, using AMPK modulating compounds and their analogs.