Aiming to access (-)-Macrolactin A total synthesis, we employed modern organometallic reactions such as Negishi, Suzuki-Miyaura cross-coupling and cross-metathesis reactions with interesting diene building blocks. Also, we investigated SmI2- mediated diastereoselective Reormatsky and envisaged to use SmI2 in interesting alkylation.
We succeed in the synthesis of the NF in 37% over 7 steps and SF in 17% over 6 steps
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