Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets

• Autores: Clara Domínguez Vivero
• Directores de la Tesis: Rogelio Leira Muiño (dir. tes.), José Antonio Castillo Sánchez (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2021
• Idioma: inglés
• Tribunal Calificador de la Tesis: Julio Pascual Gómez (presid.), Xiana Rodríguez Osorio (secret.), Isabel Pavao Martins (voc.)
• Programa de doctorado: Programa de Doctorado en Investigación Clínica en Medicina por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias de la vida
    • Inmunología
  • Ciencias médicas
    • Medicina interna
      • Neurología
    • Patología
      • Neuropatología
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Migraine is a complex disorder that involves several physiopathological mechanisms. Toll-like receptors (TLRs) are involved in neuroinflammation, but their role in migraine is not completely understood. This translational study investigates whether expression of Toll-like receptors 2 and 4 (TLR2 and TLR4) is increased in chronic migraine (CM) patients, and if TLR4 is involved in the vascular response to CSD. With this aim, we designed a clinical cross-sectional study measuring peripheral blood expression of TLR2 and TLR4 and a experimental study based on an animal model of cortical spreading depolarization (CSD). CM patients showed increased expression of TLR4 and TLR2 in peripheral blood. TLR4 KO mice had a different response to CSD stimulation that was reproduced after pharmacological blockade of TLR4. Our results suggest that TLR2 and TLR4 may have a role in migraine pathophysiology, providing a potential novel strategy for treatment.