Aportaciones al desarrollo preclínico de un medicamento oncológico infantil con excipiente o soporte
- Autores: Francesc Cano Casas
- Directores de la Tesis: José Antonio Tornero García (dir. tes.)
- Lectura: En la Universitat Politècnica de Catalunya (UPC) ( España ) en 2020
- Idioma: español
- Materias:
- Texto completo no disponible (Saber más ...)
- Resumen
The world of technical textiles is present every day in more sectors. In the work presented, a new facet of textile materials has been shown, textiles as a drug excipient and functional matrix.
It is known that electro-spinning technology has opened up a range of possibilities in the field of medical textiles. However, the environment and the requirements of the pharmaceutical sector make the implementation of any new product a long and expensive job.
This work is part of a project to develop a new medicine for both adult and paediatric cancer use. The drug that is developed uses as excipient and support matrix a non-woven formed with nanofibers made by the electro-spinning technique. During the nonwoven formation process, the active ingredient (API) is integrated into the structure. In this way, a very effective drug is produced for its intended use.
The present work focuses on finding solutions that help the development of this drug by adapting the textile production of nanofibers to the level of quality required for the production of a drug intended to be implanted inside a person. For this reason, a search has been made on the current state of the art of nanofiber production technologies. This has been done in order to ensure the production and scaling process in a future implementation in the development of the product at the commercial level.
From a development point of view, the mode of deposition of the nanofiber beam in the collector has been analysed. Theoretical concepts of a textile nature have been developed such as fibre count, deposition rate, total draw and polymer adapted to the electro-spinning technique. With these developments, new studies may be carried out that include these variables to gain an in-depth understanding of their influence on the structure of fibres and their properties, as is the case with fibres produced by conventional textile filament extrusion techniques.
Moreover, an analysis was carried out with its corresponding validation, using finite element modelling (FEM) of the electrostatic field in the electrospinning process. Thanks to this analysis, the nature of the sources of disturbance of the electrospinning beam that affect the homogeneity and therefore the quality of the generated non-tissue has been known.
As a result of the knowledge acquired with the FEM analysis, an element has been developed that guarantees the homogeneity of the fibres throughout the entire non-woven production width, thus allowing to maximize quality and production area.
