Research and development of advanced controlled drug delivery systems: application in Keratoconus and Leber´s Hereditary Optic Neuropathy

• Autores: Rubén Varela Fernández
• Directores de la Tesis: Francisco Javier Otero Espinar (dir. tes.), Isabel Lema Gesto (dir. tes.), Miguel González Barcia (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2022
• Idioma: inglés
• Tribunal Calificador de la Tesis: José Blanco Méndez (presid.), Maria Aranzazu Acera Osa (secret.), Alicia C. López Castellano (voc.)
• Programa de doctorado: Programa de Doctorado en Investigación y Desarrollo de Medicamentos por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias médicas
    • Ciencias clínicas
      • Oftalmología
    • Farmacología
      • Análisis de medicamentos
      • Preparación de medicamentos
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • In the present thesis, the research, development, and characterization processes of controlled drug delivery systems intended for the treatment of two different ocular pathologies were described. Firstly, different types of lactoferrin-loaded nanoparticles intended for topical ophthalmic administration were developed and proposed as the first pharmacological alternative for the Keratoconus (KC) treatment. On the other hand, idebenone-loaded polymeric implants and microparticles were designed and proposed as new therapeutic strategies for the treatment of Leber's Hereditary Optic Neuropathy (LHON).