Power electronics technologies for electroporation of large tissue volumes
- Autores: Borja Lopez Alonso
- Directores de la Tesis: Oscar Lucia Gil (dir. tes.), Héctor Sarnago Andía (codir. tes.)
- Lectura: En la Universidad de Zaragoza ( España ) en 2022
- Idioma: inglés
- Tribunal Calificador de la Tesis: Lluis M. Mir (presid.), Jesús Acero Acero (secret.), Fernando Burdio (voc.)
- Programa de doctorado: Programa Oficial de Doctorado en Ingeniería Electrónica
- Materias:
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- Resumen
Electroporation is a branch of electrochemistry and electrobiology. These subjects are focused on the study of the effects of electricity in materials or biological tissues. Specifically, the electroporation is a phenomenon based on the change in the permeability of the cell membrane by applying an electric field.
In the last years, electroporation has been applied in a wide number of areas, with medicine and food processing being the most relevant ones. In the medical area, electroporation has been applied to many fields from drug-based therapies to tumor ablation. However, electroporation still needs to be improved to extend and standardize its use. There are important reasons to develop electroporation medical applications. Specifically, it has great advantages in the field of electrosurgery applied to tumor treatments electroporation. Electroporation allows treating tissues with high blood perfusion, and it does not produce thermal damage. Also, this technique does not destroy blood vessels structures, what allows to preserve more healthy tissue. It is also important to note that electroporation is compatible with many of the current tumor treatments, enhancing their effects and focusing their action.
The main purpose of this research is to deepen the analysis of electroporation in order to propose new tools to carry out electroporation treatments in a safer, more controlled, and more effective way.
This dissertation has been split in 4 parts focused on a common topic, the enhancement of electroporation medical applications. To achieve this aim, two different goals have been proposed, first increase the volumes treated, and second enhanced the control and the homogeneity of the electroporation procedures. In Part I, the electroporation phenomena is presented focusing on medical applications. Part II presents and describes the results and conclusions obtained from the experimentation carried out to increase the volumes treated. In Part III, the different methods proposed and the technological developments carried out to improve the medical applications of electroporation are presented. Finally, Part IV a detailed discussion will be provided to present the main advantages and disadvantages of the proposed approaches and its implementation.
