Multicomponent synthesis of γ-lactam derivatives and applications as anticancer agents
- Autores: Xabier del Corte Solaguren-Beascoa
- Directores de la Tesis: Eduardo Martinez de Marigorta Izaga (dir. tes.), Javier Vicario Hernando (dir. tes.)
- Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2022
- Idioma: inglés
- Títulos paralelos:
- γ-laktama-deribatuen osagai anitzeko sintesia eta aplikazioak minbizi-kontrako agente gisa
- Programa de doctorado: Programa de Doctorado en Química Sintética e Industrial por la Universidad del País Vasco/Euskal Herriko Unibertsitatea y la Universidad Pública de Navarra
- Materias:
- Enlaces
- Tesis en acceso abierto en: ADDI
- Resumen
Cancer, the name given to a collection of neoplastic diseases, is the second most important global cause of death. For ages, the treatment of these diseases has been a highly complex process and, although several innovative approaches have been developed and approved for clinical use, today the prevalent general therapies are still a combination of surgery with chemotherapy and/or radiation therapy. Despite the progress made to date, there is still a serious need to find new chemotherapeutical agents that may be able to bind selective targets at a molecular level. In this context, one promising biochemical target is the interaction between p53 transcription factor, which is mutated or has its function lost in 50% of human cancers, and the MDM2 (Murine Double Minute 2) and MDMX (Murine Double Minute X) proteins. Among the different families of molecules with the capability to inhibit MDM2/MDMX-p53 protein-protein interaction, those containing a pyrrolidone core (γ-lactam), have a promising inhibitory capacity and have not been studied so far in deep.
