Pharmaceutical compounding and drug repositioning from hospital pharmacy in situations of therapeutic gap

• Autores: Ana Castro Balado
• Directores de la Tesis: Anxo Fernández Ferreiro (dir. tes.), Francisco Javier Otero Espinar (dir. tes.), Miguel González Barcia (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2023
• Idioma: inglés
• Tribunal Calificador de la Tesis: José Manuel Martínez Sesmero (presid.), Bárbara Blanco Fernández (secret.), Mónica Climente Martí (voc.)
• Programa de doctorado: Programa de Doctorado en Investigación y Desarrollo de Medicamentos por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias médicas
    • Farmacología
      • Composición de medicamentos
      • Evaluación de medicamentos
      • Preparación de medicamentos
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • This doctoral thesis focuses on offering therapeutic alternatives through pharmaceutical compounding and drug repositioning from the hospital pharmacy to cover therapeutic gaps. An ophthalmic compounded formulation of cysteamine in hyaluronic acid packaged in novel single-dose containers was developed for the treatment of ocular cystinosis. On the other hand, an inhaled compounded formulation of ethanol was developed for the treatment of SARS-CoV-2 infection, and subsequently studied for efficacy and safety in the phase II clinical trial ALCOVID-19. In both cases, appropriate galenic development and characterisation has been performed in conjunction with preclinical pharmacokinetic studies prior to appropriate translation into clinical practice.