Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts
- Autores: Paolo Francisco Sánchez Puccini
- Directores de la Tesis: Eric M. Brey (dir. tes.), Juan Carlos Briceño Triana (dir. tes.)
- Lectura: En la Universidad de los Andes (Colombia) ( Colombia ) en 2018
- Idioma: español
- Enlaces
- Tesis en acceso abierto en: hdl.handle.net
- Resumen
Due to the high mortality associated with cardiovascular diseases (CD) and alterations in the peripheral circulatory system, tissue engineering for the development of new treatments is presented as a very attractive approach. Tissue engineering seeks the development of new devices to improve current solutions and in the process increase our knowledge about the physiology of the human body to be able to obtain the greatest impact in the use of this technology in patients. This thesis is aimed at the study of the regeneration of arteries through the use of a porcine intestinal submucosa graft (SIS). Previous studies have shown the potential of this material for its use as a cardiovascular graft. In this thesis, we sought to understand the effect of the physical properties of SIS on tissue regeneration. In order to fulfill this objective, mechanical characterization, multi-scale simulation and in vivo experimentation were combined in order to understand the biomechanical environment provided by this material. Among the results obtained, it was possible to characterize the fatigue of the SIS under specific conditions of a vascular graft and to identify the effect of the orientation of the fibers in the transmission of stresses to the cells
