Epidemiology and the Burden of malaria in Mozambique, The

• Autores: José Alves Mabunda Samuel
• Directores de la Tesis: Pedro L. Alonso (dir. tes.)
• Lectura: En la Universitat de Barcelona ( España ) en 2006
• Idioma: inglés
• Tribunal Calificador de la Tesis: Núria Casamitjana Badia (presid.), Alfredo Mayor Aparicio (secret.), José María Bayas Rodríguez (voc.), Josep Maria Jansá (voc.), Agustín Benito Llanes (voc.)
• Materias:
  • Ciencias médicas
    • Epidemiología
    • Patología
      • Parasitología
• Enlaces
  • Tesis en acceso abierto en:  TDX  Dipòsit Digital de la UB 
• Resumen

  • Malaria occurs mostly in the tropical regions of the world. Sub-Saharan Africa is the area most affected. The occurrence of a very efficient mosquito vectors Anopheles gambiae complex and Anopheles funestus group sustain high transmission of the Plasmodium falciparum, the most predominant and deadly malaria parasite species. Local weather conditions are appropriate and often transmission occurs throughout the year. Limited resources and socio-economic instability constitute the major factors impeding efficient malaria control activities. The worldwide malaria eradication programme carried out during the 1950's focused mainly on insecticide residual spraying with DDT, anti-malarial drug treatment, and surveillance.Regional eradication of the disease was achieved, nevertheless, in many endemic regions of sub-Saharan Africa excluded from the eradication campaign, the disease is still afflicting their inhabitants. The malaria disease burden estimation in tropical Africa relies on mortality and morbidity data collected by the health system information. Conservative estimates of the burden of disease claim for more than 300 million clinical episodes and 1 - 3 million deaths every year and young children harbour the largest and most important portion of this bulk.Currently, the situation is deteriorating, increasing malaria-related morbidity and mortality have been reported. The rapid development and widespread of parasites strains resistant to almost all anti-malarial drugs, and vector resistance are the major contributing factors.In addition, global climate change is affecting the health of human populations, including changes in the transmission and seasonality of vector-borne diseases. The range of factors affecting transmission and distribution of vector-borne diseases, particularly malaria, include those related to temperature, humidity and precipitation. In Mozambique, malaria is endemic throughout the country, due to a multitude of factors such as climatic/environmental (favourable temperatures and rain patterns, abundant breeding sites) and socio-economical (poverty related improper housing/shelter, unaffordable preventive means). Transmission is perennial, with peaks during and after rainy seasons. The intensities of transmission may vary depending on the amount of rain and air temperature. However, at present there is a lack of good quality and updated information on the endemicity levels in the country.The country-wide malaria survey carried out between 2002 and 2003 aimed to determine the prevalence and intensity of Plasmodium infections, the prevalence and the severity of anaemia in children under 10 years of age and in pregnant women across different ecological settings, in order to characterize the malaria transmission intensities and to estimate the disease burden in Mozambique. The last comprehensive malaria survey in the country was carried out in 1952. For that reason, this survey was an unique opportunity to perform a sound methodological assessment of the current epidemiological malaria situation in the country. Based on altitude and on geographical region differences samples were collected from stratified areas distinguished as coastal, plateau and highland strata, in the northern, centre-northern, central and southern regions. For sampling at community level, in each of those stratified areas, a modified cluster sampling method with 30 clusters, used by WHO for evaluation of coverage of the Expanded Programme of Immunization was adopted. The study consisted of house-to-house survey, in 24 districts randomly selected. A total of 12,002 subjects including children less than ten years of age and pregnant women were enrolled. The malariometric survey consisted of finger pricking and blood collection to prepare thick and thin film for malaria parasite species identification, and respective density and determination of haemoglobin concentration. Measurement of axillary temperature and in those with fever a rapid enzyme test for malaria diagnosis was performed. The entomologic survey consisted of pyrethrum spray knock down mosquito collections. In total 6,557 female anopheline mosquitoes caught in 1,440 dwellings, were analysed for sporozoite infection using PCR techniques and the entomological inoculation rates were determined for each strata across regions.