Moléculas séricas relacionadas con la fisiopatología del adenocarcinoma pancreático como posibles marcadores tumorales
- Autores: María José Ferri Iglesias
- Directores de la Tesis: Rosa Peracaula Miró (dir. tes.), Rosa Aleixandre Cerarols (dir. tes.)
- Lectura: En la Universitat de Girona ( España ) en 2012
- Idioma: español
- Tribunal Calificador de la Tesis: Juan Figueras Felip (presid.), Rut Porta Balanya (secret.), José Manuel Fernández Real Lemos (voc.), Marc Sáez Zafra (voc.), Aurelio Tobías Garcés (voc.)
- Materias:
- Enlaces
- Tesis en acceso abierto en: TDX
- Resumen
Serum levels of several molecules associated to pancreatic adenocarcinoma (PDAC) pathophysiology are evaluated in this work, in order to determine their diagnostic value, distinguishing between PDAC patients and healthy controls (HC), different gastrointestinal tumours (GIT) and chronic pancreatitis (CP). Plasma mRNA levels in plasma of sialyltransferases (ST3Gal III and ST3Gal IV) could differentiate between HC and PDAC. Moreover, lower levels of ST3Gal III in early stages of PDAC compared to PDAC advanced stages were reported. The Glasgow Prognostic Score (GPS), inflammatory response quantification, differentiated between all the study groups. IGF-1 levels were lower in neoplasic groups of patient vs HC and CP. We assessed the diagnostic capacity of different markers alone or in combination and compared with that of CA 19.9. The best diagnostic capacity was found combining CEA, CA 19.9 and IGF-1 compared with CA 19.9 and it could be useful to distinguish PDAC from CP.
