Resumen de Nuclear Receptor Ligands and Cofactor Recruitment: Is There a Coactivator “On Deck”?

Kendall W. Nettles, Geoffrey L. Greene

• Farnesoid X receptor (FXR) is a bile acid sensor that regulates lipid homeostasis. New structural data suggest that, unlike other nuclear receptors, FXR contains a second coactivator binding site and binds bile acids with the steroid backbone flipped head to tail, both of which have important functional ramifications.