Resumen de La energía de activación como marcador de heterogeneidad enzimática: Utilidad en bioquímica clínica
The energy of activation (Ea) may provide interesting data in the studies of enzyme heterogeneity characterization, both for enzyme systems having true isoenzymes or molecular forms with a post-transcriptional source. In this article a bibliographical review is carried out on the previously published results for several enzymes with diagnostic usefulness, as the creatine kinase, a-amylase, lactate dehydrogenase, aspartate aminotransferase, alkaline phosphatase, ?-glutamyltransferase, 5´-nucleotidase, alanine aminopeptidase, and ß-N-acetylhexosaminidase. Likewise, possible investigation lines are suggested, in which this thermodynamic variable would to give interesting data for other enzymes with clinical usefulness
