Resumen de Monkey-adapted HIV-1 highlights in vivo significance of restriction factors

Andrea Kirmaier, Welkin E. Johnson

• HIV-1 was isolated 31 years ago, yet models for studying HIV-1 pathogenesis in vivo are still lacking. Recent experiments using an HIV-1 strain engineered to replicate in macaques recapitulate several important features of human AIDS, and provide insight into the genetics of cross-species transmission and emergence of pathogenic retroviruses.