Recruiting the Students To Fight Cancer: Total Synthesis of Goniothalamin

• Autores: Fady Nahra, Olivier Riant
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 92, Nº 1, 2015, págs. 179-182
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • A modified total synthesis of (S)-goniothalamin is described for an advanced course in organic chemistry. This experiment gives students an opportunity to handle organometallic reagents and perform an enzymatic kinetic resolution and a metathesis reaction, all in the same synthesis. Furthermore, students learn flame-drying techniques for the manipulation of air-sensitive materials and high-performance liquid chromatography handling and analysis, thus strengthening their experimental knowledge.