Microwave-Assisted Hydantoins Synthesis on Solid Support

• Thibault Coursindel ^[1] ; Jean Martinez ^[1] ; Isabelle Parrot ^[1]
  1. [1] Université Montpellier 2, France
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 87, Nº 6 (June), 2010, págs. 640-642
• Idioma: inglés
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• Resumen

  • In this laboratory activity, students are introduced to a three-step synthesis of hydantoin (imidazolidine-2,4-dione), a moiety that is found in many biologically active compounds. Using a microwave oven and solid-support technology, this synthetic experiment is designed for masters-degree candidates working in organic chemistry or upper-level undergraduate chemistry students interested in solid-phase synthesis. A colorimetric test is used to monitor the reaction on the solid support and analytical techniques such as high-pressure liquid chromatography, mass spectrometry, and nuclear magnetic resonance are used to assess the product purity and yield.