Resumen de Measurement of Postmortem 1,5-anhydroglucitol in Vitreous Humor for Forensic Diagnosis
Tomoyo Takata, Yukie Yamasaki, Takashi Kitao, Satoru Miyaishi
In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5-anhy-droglucitol (1,5-AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5-AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5-AG concentrations in vitreous humor (mean+_SD: 20.2+_ 8.7 lg/mL) and CSF (16.8 *-8.7 lg/mL) did not differ significantly and showed a strong correlation (r2= 0.87, p < 0.01). These results suggest that the vitreous humor 1,5-AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5-AG concentration.
