Resumen de Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

Jan H Bergmann, Mariluz Gómez Rodríguez, Nuno M. C. Martins, Hiroshi Kimura, David Kelly, Hiroshi Masumoto, Vladimir Larionov, L. E. Jansen, William C. Earnshaw

• Here, centromeric histone marks on a human artificial chromosome are found to resemble the chromatin landscape in transcribed genes, and selective manipulation shows them to govern the incorporation of the centromere-specifying CENP-A histone variant.