Resumen de Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages

Carmen G. Palii, Carolina Pérez, Zizhen Yao, Yi Cao, Fengtao Dai, Jerry Davison, Harold Atkins, David Allan, F. Jeffrey Dilworth, Robert Gentleman, Stephen J. Tapscott, Marjorie Brand

• Expression of the basic helix-loop-helix transcription factor TAL1/SCL is required for erythrocyte differentiation; aberrant expression in lymphoid cells leads to oncogenic transformation. Here, global analysis of TAL1 binding in erythroid and malignant T cells identifies cell type specific functional interaction with the transcription factors RUNX and ETS1.