Resumen de Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

Maruf M.U. Ali, Tina Bagratuni, Emma L Davenport, Piotr R Nowak, M. Cris. Silva-Santisteban, Anthea Hardcastle, Craig McAndrews, Martin G Rowlands, G. J. Morgan, Wynne Aherne, Ian Collins, Faith E Davies, Laurence H. Pearl

• In the endoplasmic reticulum, unfolded proteins stimulate Ire1 autophosphorylation and RNase activity. The crystal structure of the dephosphorylated kinase/RNase domain of human Ire1 bound to ADP provides insight into the autophosphorylation reaction.